Jill Rourke
Publications
PubMed-NCBI author search for Dr. Jillian L. Rourke:
Sample publications
Rourke, J. , Hu, Q., and A. Screaton, R. (2017) AMPK and Friends: Central Regulators of β Cell Biology. Trends in Endocrinology & Metabolism 29. https://www.sciencedirect.com/science/article/pii/S1043276017301686
Robitaille, K., Rourke, J. , McBane, J., Fu, A., Baird, S., Du, Q., et al. (2016) High-Throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation. The Journal of biological chemistry 291. http://www.jbc.org/content/291/9/4614.full
Rourke, J.L. , Dranse, H. J., & Sinal, C. J. (2015). CMKLR1 and GPR1 mediate chemerin signaling through the RhoA/ROCK pathway. Molecular and Cellular Endocrinology, 417, 36-51. https://www.sciencedirect.com/science/article/pii/S030372071530068X
Rourke, J.L. , Muruganandan, S., Dranse, H. J., McMullen, N. M., & Sinal, C. J. (2014). Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice. Journal of Endocrinology, 222(2), 201-215. https://www.researchgate.net/profile/Jillian_Rourke/publication/262843779_Gpr1_is_an_active_chemerin_receptor_influencing_glucose_homeostasis_in_obese_mice/links/560ebaed08ae6b29b499a351.pdf
Rourke, J.L. , Dranse, H.J., and Sinal, C.J. (2013) Towards an integrative approach to understanding the role of chemerin in human health and disease. Obes Rev 14: 245-262. https://onlinelibrary.wiley.com/doi/pdf/10.1111/obr.12009
Education
Ph.D. Pharmacology, Dalhousie University, 2015.
Investigating differential signaling and functions of the chemerin receptors CMKLR1 and GPR1
B.Sc. Honours, Biochemistry and Molecular Biology, Dalhousie University, 2009.
Seeking a function for the yeast Niemann-Pick C-related gene (NCR1)
Academic experience
- Assistant Professor, Chemistry and Biochemistry, Mount Allison University 2018
- CIHR Postdoctoral Fellow, SunnyBrook Research Institute, Toronto, Canada, 2015-2018
Discovering novel regulators of human beta cell proliferation
Teaching
- BIOC 1001 Introductory Biochemistry
- BIOC 3031 Molecular Analyses
- BIOC 3051 Molecular Immunology
- BIOC 4031 Signal Transduction
- BIOC 4951 Methods in GPCR Research (I and II)
Research
Our lab focuses on the molecular biology and biochemistry of G Protein-Coupled Receptor (GPCR) signal transduction, cell function, and hormone secretion.
With more than 800 characterized GPCR sequences, they are the largest family of cell-surface receptors in the human genome.
Our research is conducted by qualified and passionate undergraduate students who aim to identify the ligands of orphan GPCRs and characterize these particular receptors, to study their role in disease and as potential therapeutic targets.